productdatasheet


RecombinantHumanCardiacTroponinC(TnC)


CatalogNumber

Size

24000P-20

20ug

24000P-100

100ug

24000P-1000

1000ug

CatalogNumber

Size

24000P-20

20ug

24000P-100

100ug

24000P-1000

1000ug

ORDERINGINFORMATION


Formulation:Sterile-filteredsolutionin150mMNaCl,10mMsodiumphosphate,pH7.0,and0.05%sodiumazide.

Purifiedbyproprietarychromatographictechniques.


BACKGROUND

Troponinisafundamentalregulatoryproteinofstriatedmusclecontraction,and,togetherwithtropomyosin,ispositionedontheactinfilament.

Troponinhas3subunits:TnI,theinhibitorofactomyosinATPase,TnT,whichcontainsthebindingsitefortropomyosin,andTnC,theproteinencodedbytheTNNC1gene.BindingofcalciumtoTnCstopstheinhibitoryactionofTnI,allowingtheinteractionofactinwithmyosin,thehydrolysisofATP,andthegenerationoftension.

MutationsintheTNNC1genearelinkedtocardiomyopathydilatedtype1Z.


DESCRIPTION

RecombinantHumanTnCproducedin

E.coliisasingle,non-glycosylatedpolypeptidechainwithamolecularweightof18kDa.


SPECIFICATIONSUMMARY

Source:Escherichiacoli

Purity:Greaterthan95%asdeterminedbySDS-PAGEandRP-HPLC.

Accessionnumber:P63316


STORAGEANDSTABILITY

Althoughstableatroomtemperaturefor3weeks,productisbeststoredat4oC.Additionofacarrierprotein(suchas0.1%HSAorBSA)isrecommendedforlong-termstorage.


Forinvitroinvestigationaluseonly.Notforuseintherapeuticordiagnosticprocedures.


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